ACE2 decoy receptor generated by high-throughput saturation mutagenesis efficiently neutralizes SARS-CoV-2 and its prevalent variants고처리량 포화 돌연변이 유발에 의해 생성된 ACE2 미끼 수용체는 SARS-CoV-2 및 그 유행하는 변이체를 효율적으로 중화합니다Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 binding ACE2-RBD binding approach binding binding affinity C-terminal cellular receptor changes in convalescent sera Critical critical point D614G decoy receptor domain Effect fused global pandemic glycosylation site High-throughput screening increase in Microarray monoclonal antibodies Mutagenesis mutations neutralization neutralize neutralized Omicron variant Point mutation prevalent protease Protein protein engineering. Pseudotyped virus RBD RBD binding RBD-ACE2 receptor Receptor binding domain rescued SARS-CoV-2 SARS-CoV-2 virus significantly single-cell soluble ACE2 Spike protein the SARS-CoV-2 the SARS-CoV-2 virus therapeutic potential Treatment Vaccine variant variants viral entry viral spike protein wild-type [DOI] 10.1080/22221751.2022.2079426 PMC 바로가기 [Article Type] Article
ACE2 N-glycosylation modulates interactions with SARS-CoV-2 spike protein in a site-specific mannerArticle Published on 2022-11-052022-11-16 Journal: Communications Biology [Category] SARS, 변종, [키워드] accumulated ACE2 ACE2 receptor binding binding site caused cellular changes in conserved Delta glycan glycosylation glycosylation deletion glycosylation site Guidance Interaction investigated lineages modulate mutated N-glycosylation omicron parental profile provide SARS-CoV-2 SARS-CoV-2 spike protein soluble ACE2 spike spike mutation the SARS-CoV-2 therapeutic use variant variants of concern virus VOCs [DOI] 10.1038/s42003-022-04170-6 PMC 바로가기
Early shedding of membrane-bounded ACE2 could be an indicator for disease severity in SARS-CoV-2Article Published on 2022-10-012022-11-15 Journal: Biochimie [Category] COVID19(2023년), SARS, 바이오마커, [키워드] ACE2 Admission association Biomarker circulating Comorbidities Course COVID-19 COVID-19 patient COVID-19 patients D-dimer Diabetes Mellitus disease disease severity early phase effective ELISA healthy controls host receptor hypertension increase in Infection investigated involved marker membrane moderate outcome plasma Plasma level positive correlation sACE2 sACE2. SARS-CoV-2 Severe case shown significant increase soluble ACE2 the SARS-CoV-2 was determined was obtained was performed [DOI] 10.1016/j.biochi.2022.06.005 PMC 바로가기
Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variantsSARS-CoV-2 변종을 차단하는 범용 약제로서의 임상 등급 ACE2Article Published on 2022-08-082022-09-11 Journal: EMBO Molecular Medicine [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE2 Alpha analyzed Beta binding affinity caused clinical clinical trial COVID-19 Delta develop Efficacy epithelial cell epithelial cells Gamma human lung human lung epithelial cells independent Infection inhibit inhibited neutralized neutralizing antibody omicron Phase 2 principle proof reduced SARS-CoV-2 isolates SARS-CoV-2 variant SARS-CoV-2 variants several variant several variants soluble ACE2 strain tested therapeutic Therapeutic strategies therapeutic strategy These data Treatment Vaccine vaccine. variants variants of concern VeroE6 cell VeroE6 cells VoC [DOI] 10.15252/emmm.202115230 PMC 바로가기 [Article Type] Article
Engineering ACE2 decoy receptors to combat viral escapabilityReview article Published on 2022-07-252022-10-05 Journal: Trends in pharmacological sciences [Category] COVID19(2023년), SARS, 변종, 비임상, [키워드] ACE2 ACE2 decoy receptor acute respiratory distress approach ARDS biologic cell entry Clinical studies coronavirus Coronaviruses COVID-19 decoy Defense Engineering entry receptor enzyme escape mutation Fc-receptor engagement help high-affinity mutagenesis highlight Immune cell Mutagenesis preclinical study receptor receptor protein receptors recombinant recombinant ACE2 Safe soluble ACE2 syndrome therapeutic efficacy viral escape virus [DOI] 10.1016/j.tips.2022.06.011 [Article Type] Review article
Development of an aerosol intervention for COVID-19 disease: Tolerability of soluble ACE2 (APN01) administered via nebulizerCOVID-19 질병에 대한 에어로졸 중재 개발: 분무기를 통해 투여되는 가용성 ACE2(APN01)의 내약성Article Published on 2022-07-112022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 비임상, 임상, [키워드] ACE2 Administered administration aerosol aerosolization airways Ang II angiotensin binding binding activity breath catalytic caused cleavage clinical trial Concentration conducted COVID-19 Critical deregulated development Efficacy enzymatic activity evaluated Evidence evidence of feasible healthy volunteer healthy volunteers in vitro individual Infection initiated Intervention Kinin limit lung lung damage mitigate mouse model neutralization neutralize notable Pathways phase preliminary evidence RAS RAS activity recombinant ACE2 Renin SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor Signaling soluble ACE2 Spread subsequent Tolerability toxicities virus [DOI] 10.1371/journal.pone.0271066 PMC 바로가기 [Article Type] Article
Decrease in Angiotensin-Converting Enzyme activity but not concentration in plasma/lungs in COVID-19 patients offers clues for diagnosis/treatmentResearch article Published on 2022-07-062022-10-05 Journal: Molecular Therapy [Category] 바이오마커, 변종, 임상, 치료기술, 치료법, [키워드] ACE2 activity/concentration biomarker in plasma/saliva Corona virus COVID-19 disease RAS pathway soluble Angiotensin-Converting Enzyme 2 ACE2 acute respiratory syndrome age angiotensin-converting-enzyme Autopsy Biomarker clinical observation Concentration condition Control convalescent coronavirus disease Coronavirus-2 COVID-19 COVID-19 patient disease disease severity dysregulation evaluate evaluated Hospitalization hospitalized COVID-19 patient human cell infect inverse correlation lung mACE2 marker membrane nadir no difference Non-COVID-19 offer Patient patients plasma Plasma marker plasmas quantitative test quarantine receptor reduced renin-angiotensin system restored sACE2 Saliva saliva marker SARS-CoV-2 SARS-CoV-2 diagnosis/treatment soluble ACE2 statistically therapeutic target tissue treat variations volunteers [DOI] 10.1016/j.omtm.2022.07.003 [Article Type] Research article
Engineering defensin α-helix to produce high-affinity SARS-CoV-2 spike protein binding ligands고친화성 SARS-CoV-2 스파이크 단백질 결합 리간드를 생성하기 위한 디펜신 α-나선 공학Article Published on 2022-06-012022-09-11 Journal: Protein Science : A Publication of the Protein Soc [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 ACE2 protein acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha Amino acid amino acid residue amino acid residues angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Bacterial binding binding ligand blocked class competitive inhibition coronavirus COVID-19 Critical defensin demonstrated diagnostic diagnostics disrupt Disulfide Engineering exceptional expressed expression high-affinity binding homogeneity host cell host cells initial Interaction kDa Ligand ligands Protein protein-protein interaction purified receptor residue SARS-CoV-2 SARS-CoV-2 diagnostics SARS-CoV-2 neutralizing antibodies SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus soluble ACE2 Spike protein spike-protein spike-protein. the SARS-CoV-2 the spike protein therapy viral infection were used α-helix [DOI] 10.1002/pro.4355 PMC 바로가기 [Article Type] Article
Evidence in favor of the essentiality of human cell membrane-bound ACE2 and against soluble ACE2 for SARS-CoV-2 infectivitySARS-CoV-2 감염성에 대한 인간 세포막 결합 ACE2의 필수성과 가용성 ACE2에 대한 증거Comment Published on 2022-05-262022-09-11 Journal: Cell [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 favor human cell membrane-bound SARS-CoV-2 soluble ACE2 [DOI] 10.1016/j.cell.2022.05.004 PMC 바로가기 [Article Type] Comment
Genetic Landscape of the ACE2 Coronavirus ReceptorACE2 코로나바이러스 수용체의 유전적 지형Meta-Analysis Published on 2022-05-032022-09-11 Journal: Circulation [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] ACE2 ACE2 protein Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 biological systems blood immune cells cardiometabolic cardiovascular disease cardiovascular diseases cardiovascular diseases. Cell cell type circulating Clinical studies clinical study Combined complex complex disease conducted coronavirus correlated correlation COVID-19 COVID-19 severity cross-sectional Diseases DNA methylation elevated epidemiological epigenomic expressed functional gastrointestinal tracts Genetic genetic architecture Genome genome-wide association Genome-wide association study heart heritability Hospitalization Human human cell human cells immune cells in silico individual Infection landscape likelihood loci mapped medications mendelian randomization Meta-analysis Odds ratio outcome Phenotypes plasma Protein Quantitative randomization receptor Regulatory related diseases resource respiratory SARS-CoV-2 severe COVID-19 soluble ACE2 suggested tissue transcriptomic Treatment variant Vascular vascular disease vascular diseases [DOI] 10.1161/CIRCULATIONAHA.121.057888 PMC 바로가기 [Article Type] Meta-Analysis